Ubiquitin and Autophagy

Abstract

This Special Issue of Cells on “Ubiquitin and Autophagy” is a tribute to the multifaceted role of ubiquitin and ubiquitin-like proteins in autophagy-related pathways. Ubiquitin is a small regulatory protein that is used to modify other proteins in the process called ubiquitination. The polyubiquitination of proteins in protein aggregates, at the surface of organelles and intracellular pathogens often leads to sequestration of these structures from the cytosol by autophagosomes and their delivery to the lysosomes for degradation and recycling. We are particularly interested in research articles and reviews at the intersection of ubiquitin-related processes and autophagy, including the roles of ubiquitin ligases and proteases in autophagy; ubiquitination and deubiquitination of autophagic substrates and players; ubiquitin-binding autophagic adaptors and their roles in selective autophagy; ubiquitin-like autophagic proteins and their conjugation systems; etc.